NTSC, Full size 1.35GB, individual save grabbed from my real memory card, size was 2.00MB and on nintendont I have it set to 251 multi off. I enabled disc drive led but i'd doubt that would cause corruption
Disable the LED option, you never know when another setting might be an issue with something else.
One example is what happened to sonictopfan, he was having an issue with the discs not swapping properly, and we found out that the issue was because he was using a Multi-save.
Try it without the LED option, because I have played PP before and have never got any problem with the save being corrupted.
Same as you, NTSC, full and only with MC enabled.