D
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OP
so with that you mean to put the iso in a clear path like Windows/Users/Sonia/Downloads/Game.iso?If the path has any special characters it won't work like &. So if your iso is inside of a folder named "Simpsons Hit & Run" that's your problem. Rename the folder without the & or any other special characters and retry it.
Copy/paste your path to the iso here just right click on the top bar and select "copy paste as text" and paste it here.
gcn, ps2, xbox and pcPardon my ignorance but, is that game for gbc or gcn?