NoNpDRM is essentially a plugin that creates "fake" licenses for official games. What this basically means is, instead of having to use semi-broken tools like Maidump or Vitamin to decrypt and backup Vita games, we can play normal, encrypted Vita backups as if they were our own game. This is beneficial because Vitamin and Maidump games are kind of broken, in the sense that they caused various issues like saves getting deleted if your Vita was put to sleep. This also rendered games that were undumpable on 3.60 (and didn't require 3.61+), like Axiom Verge, to be fully playable. If you use Vita backups, 99% of the time you're going to want to grab NoNPDRM dumps as they're one of the cleanest (besides psvgamesd, which produces 1:1 dumps).
ReNpDRM and ReStore are both plugins that essentially gave us back access to PSN and the PS Store on 3.60. These plugins are, unfortunately, very temperamental in whether they want to work or not, and as of now are no longer required as 3.65 still has access to PSN and the PS Store natively.
DownloadEnabler is a plugin that allows you download whatever files you like from the stock browser, so you're no longer limited to certain file types.
With PSVimgtools, use QCMA. CMA usually forces you to update to the latest firmware, QCMA you don't have to.
You also don't have to use mltactivator any more, since we have access to PSN with 3.65 you can activate using the native activator. Though it should be noted that activation is no longer required for any homebrew, so there's no real benefit beyond PSN-related stuff.
Using a new account may cause some backups to be unusable, but in this case you can use something like Account Switcher which lets you switch between various accounts on one memory card to restore the backups if need be.
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