For the sound issues, Sparkster has it somewhat bad. Lufia II has it as well but AFAIK it's very minor. (For the record I injected these manually a good while ago)
Also there's a few games I've injected where there was no option to use save states, and didn't give a prompt upon opening the menu for the first time. I don't remember which ones though...
Star Ocean might not have a problem if you inject it into SFA2, since it uses the same chip. Regards to size, I don't know. It's quite large at 48 megabits but NSRT lists it as LoROM and not Extended, unlike Chrono Trigger Retranslation which is Extended HiROM (Same size, and black screens right after you start the game). I'll try injecting it and see how it goes.
Edit: Didn't work. Oh, well...