Yes, obviously some changes can break things in loaders, we've seen a few examples already with GX having to get updates just to get nintendont to work again there. Even so, there can be other reasons, like the SD or HDD used, the way an HDD is setup, if the rip for the game was well made or not, even the simple fact of using an SD instead of an HDD, since they use different kernels. Giving more information is good of course, but even so, I'm sure most of us wouldn't figure out the reason it's not working just from that.