there are none that i can think of, but there are some that have used halfway that size. Professor Layton and the Unwound Future comes to mind. i think it's mainly the animated cutscenes that take up all that space though, which is pretty neat if you ask me. also, DQIX, Infinite Space, and a few others also use the same file size. oh and Pokemon Black/White. but no english language 512MB games yet (unless you count the Love Plus translation).