Never used Meth at all but I've taken Dextroamphetamine(Dexadrine) as well as Adderal(75% Dextroamphetamine, 25% Levoamphetamine) with Dexadrine being the far cleaner, superior high but stimulants generally aren't my thing and I only messed with them for a short period in HS; they're quite dangerous because they drastically raise heart rate and blood pressure among other things. I've never tried MDMA but I've used Methylone which is akin to a milder MDMA effects-wise apparently, but I can't compare it to MDMA myself. I've used Cocaine a few times(snorted) and while its high is very intense, it only lasts around 30-45 minutes and the comedown really sucks; not worth it. Opiates in the form of dried poppy pods that I performed extractions on(raw opium) was my main demon though as well as nicotine, and if I could go back in time I'd avoid opiates & Nicotine. Stay away from opiates, nicotine and other highly addictive substances!
Other than that, most of my drug experiences involved copious amounts of cannabis combined with mushrooms, 4-aco-DMT, 2C-E, Salvia, tried Mescaline once in the form of Peruvian torch cactus(puked so only got a low dose) and even DXM which I also regret using(the shit in some cough syrups). I've used some other RCs as well but I've never tried LSD due to unreliable sources/purity. Basically, I did a ton of very stupid shit when I was younger but I also learned some very valuable lessons and became much more humble due to addiction and seriously intense trips that gave me out-of-body experiences, especially when I took between 7-8 grams of Cubensis shrooms. Psychedelics are not to be toyed with and if you're just looking for a nice buzz with pretty colors, you will be blown away by the intense mindfucks many psychs induce.
Really, the only drug I consider safe to use regularly is weed(alcohol included of course) and you shouldn't smoke it. Vape or eat it if you decide to use it regularly because smoking anything is absolutely awful for you. You're inhaling burning toxic chemicals, not just THC and other cannabinoids.