Roguelike Souls overhauls the Dark Souls experience entirely by replacing the game's progression with a roguelike system not unlike The Binding of Isaac or Dead Cells.
In each "run" through Lordran, you are tasked with conquering a semi-random sequence of levels containing random enemy types in completely random positions (not just existing enemy positions), fresh random loot, and random bosses, as well as a few other random events and risk/reward scenario. You can also create one bonfire per level, anywhere you want.
If you die five times, your progress in that run will be lost and you will be sent back to Firelink Shrine to start anew.
Allies you rescue (from fixed locations) will permanently reside at Firelink to provide gameplay-modifying bonuses, and certain game progression events will unlock more loot options, but nothing else will persist between journeys through Lordran.
In addition, every time you install the mod, a fresh set of procedurally-generated weapons, armor, and spells will be created as loot.
By default, enemy animation speeds are also randomized, with each animation potentially becoming slightly weaker + faster (up to a point) or stronger + slower.
This can sometimes lead to particularly brutal foes who get lucky and have most of their attacks sped up (the "Card Of" phenomenon), so you can either re-install the mod to roll the dice again, or use an installation option to disable enemy speed changes altogether.
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