From where I sit
Loss of schooling
Loss of social life
Loss of business large, small and incidental.
Loss of funds from government pools of money that do good stuff otherwise.
General side effects of sitting in the house -- whether it is becoming fat bastards, bouncing each other off the wall because no personal space or generally just bastards.
Lack of diagnosis options for other serious illness.
Right to run around, taking the risks you will or won't, is generally recognised is one enjoyed by those in free countries. Not something that should be surrendered lightly as a general matter of principle.
Handful of old people and sick people that might well have been able to hide out anyway kicking the bucket a few years ahead of best case. When it was an unknown then numbers might have been higher, today we have had enough cases vs deaths/serious negative long term outcomes to make as good a model as we have for almost any disease in the modern world.
Those that don't die might end up costing resources.
Long term some unknowns as to what goes.
More cases, more risk of a mutation worth noting (more deadly, more spreadable by whatever means).
Efficacy of lockdown both in theory, numbers shown (we have nice data for a regression analysis right now if you want) and reality -- compliance rates is a factor in all medication type scenarios (if you can't not drink then no liver transplant, if you can't take care of yourself then again transplants and treatments get altered, if you can't draw blood and titrate new levels hourly then probably going to be in hospital or specialist facilities...).
Right now we seem to have a nice
"They are working the numbers are dropping"
"They are not working people are going outside"
Seems like a damned if you do, damned if you don't type deal there.
Run me a proper risk, reward cost-benefit type analysis such that we might be able to quibble our corner for our respective risk tolerances. Lives saved is certainly nice but not at any price, indeed there already appears to be some assignment of the value of lives. Quite happy to have benefits if vaccination efficacy and schedule can be determined be a factor in this as well and the delta there makes sense. As it stands though if they suddenly determined "oh wow look two doses of saline a week apart acts as basically 100% inoculation" then what would that timeframe be -- 60 million people in the country, however many minutes per setup but can be administered by any medic (how many of those exist?), 120 million needles needed (big but probably doable, call it 150 to account for droppages and make distribution easier), might be able to skimp and use disposable ends though. Running that and it is not a short process even in that kind of best case pondered there, how many doses can be produced, what the practical efficacy is (I am seeing rather low numbers for some of them, even if net positive) distributed and given (even before we have those that think it might give them lizard change abilities/the mark of the beast/infertility*, actual medical reasons not to -- 1.8-2.0% allergic to eggs for one, or just care to wait for v3 for fear corners were cut) will likely only make that harder. Numbers administered already are not that high (600k is a lot, but in terms of population if rates do need to be 90% or more still means next winter. Potential to ramp up distribution given that there were months to put it in place already as trials looked certain could make more but how much is realistic here? Is then waiting for some measure of vaccination level worth the tradeoff?
*never mind that a two injection long term infertility causing treatment would be worth a bloody fortune rather than having to do tubal ligation or vasectomy.
As nobody appears to be doing that then I am left to question the merits of things until such time as someone does, and ponder whatever scraps of information I might get and put it into models I am not necessarily the best equipped to ponder.
Being told shut up it is good for you by people that I would normally not trust to organise a piss up in a brewery, read a map or hold my pint while I tie my shoe, never mind the demonstrable evidence of their incompetence at any number of things does not inspire confidence in words.