I've tried them all. Mainly for GAD, that happened after a surgery. The number one thing I hated about ADs was lack of feeling. There were others with bad side effects for me, Cymbalta...that was not a cool one, and Lexapro...that one is a stay away forever one for me. If I was forced to pick one it would be Zoloft followed by Prozac. Im staying far and away from them atm. Living in chronic pain isn't helping but for those SSRIs and SNRIs the DRs can keep them. The best help is Cognitive Behavioral Therapy. I had a Psychologist that was great, just damned expensive...surprising how simple things you can do help calm anxiety and lessen depression without a dependency on meds.