neogamma comes with *.wip files to get around the protection for NSMB. All you need is a working cIOS249 and Neogamma (w/ *.wip files) and it should work automatically (provided your wii is even capable of playing burned discs).
Or u could hex edit the main.dol of the ISO so that the game will work even without *.wip files (required if the game is being played via darkcorp/disc channel or if you do not always have an SD card to load the *.wip file). If u search for it, u should find a post by WiiCrazy (I think) outlining exactly what values need to be hex edited. Just extract the main.dol using wiiscrubber, open it in a hex editor, change it, save it, replace the main.dol with the modified one. Done