The Slot 2 cards are done for, Slot-1 is perfect for DS games with easy firmware updates, and no patching for roms or homebrew, whilst the EZ Flash 3in1 is the perfect companion to play GBA games, and the DSTwo has a GBA emulator.
There's just no place for Slot-2 cards any more, which is sort of a shame because they are actually AWESOME rom dumping utilities.