Scanning around and going back into memory there have been a few comic/superhero shows without superheroes (which I will define as anybody without powers above and beyond the average human with possible further exceptions if it is a weaker power like "ability to detect evil" as in the case of something like night man -- this does mean "seriously highly trained" people do not count as well, iron man (barring things like extremis) does count though). The list of pilots, minor network small runs, cartoons/one of animated shows and more is not inconsiderable. Add in things that blur lines a bit (there were a few in the 80's and 90's).
On the other hand I do like the Punisher, enjoyed some of the CW fare where this sort of thing is a staple and have yet to see this so I am not holding out that something reasonable might come of it.
