By virtue of DVD drive read speeds, USB loading is faster than cIOSCORP and even untouched Wii disc drives. When was the last time you played Metroid Prime 3 with virtually no door lag from a disc?
cIOSCORP/cIOS disc loading: 3x read
Native disc, w/ or w/o modchip: 6x read
USB: USB2 transfer limit (up to ~12x)
As for changing settings - it's a toggle switch in whatever USB loader you use. It takes me less time to install a game to my WBFS partition, change the settings in WiiFlow, and create a Loadstructor/Crap channel loader (about ten minutes total) than it ever did to burn and verify a DVD at 2x write speed (20mins).
I think I'll take higher play speeds, simple and clean GUI, no disc swapping, and speedy installation over a small improvement in ease of use.