No, needs to be MBR and fat32. I've run a 10TB drive in a Samsung/Maxtor case (D3 Station, you can get them on e bay).
Well just for the fun of it and to keep my OCD happy I'll probably run through things anyways. It won't take long to reformat and change the cluster size 5 or 6 times.
Then I'll change it to MBR and play through the NTFS & FAT & clusters sizes again to see what's working, well beside the FAT32 256k I have my other one set to.
If anything else works I'll post an update.