I know I'll Want to wait until the 2nd iteration...especially if they did something crazy awesome like worked out a contract with Sprint or something for a 3G/4G connection (Skype video-chat app + Always online multiplayer 3DS games? Yes.).
Unfortunately, it probably will be a 2 to 3 year wait for something like that to work out, and I'll probably want to get a PSP2 by then (unless Sony repeats its primary mistake of, "be happy with what you got").
Argh- guess I'll just wait to see what games come out at launch, and what the reviews are like. It would really suck to see a 3DS 3G at E3 next year (unless, of course I don't buy the 1st iteration).