It's an hp computer
It is a USB 3.0 Port, unfortunately. So, there are a few possible options you can use. This does not mean you have "no way" of using the port. There may be another conflict at work. But, generally, 3.0 Ports do not play well with the NES Mini. I have had many switch to 2.0 Ports and be fine! You can try going into your BIOS Settings, when booting up the computer, and disable 3.0 functionality for USB and/or enable legacy device support for older 2.0, etc devices! You may also get decent results using a 3.0 to 2.0 USB Adapter. These are cheap, and may be worth a few bucks to test out. They have worked for me in other Computers I have troubleshooted with Older Hardware Setups and Configurations!
But, getting back to my original "no way". You may potentially, also have virus protection, or lack true Administrative Rights, as far as being able to actually do anything with the Mini NES. Hakchi2, generally false positives many Virus Protections, especially Norton. In several instances, I had to help people completely uninstall Norton, just to get the Mini to work. Then, reinstall Norton! It varied, case by case, depending on how Norton was initially configured!
So, for now, I would recommend trying to get into BIOS, and hopefully...you have an option to disable 3.0! Let me know, I can advise you of other things to try or do.