I find it funny that so many people are worried about an ISO loader saying it will kill the Wii. Like over 50% of those people already have a modchip, and I'm sure atleast half of the rest have some kind of pirated VC game, be it injected or a proper release.
Lets check the facts.
GC - ISO Loader
PS2 - ISO Loader
Xbox - ISO Loader
PSP - ISO Loader
Hell even the DS and GBA allow you to boot Images of retail games with a hardware modification.
And the PSP is the only system that seemed hurt from it, although it never sold well to begin with, and since M33 firmware they have been selling more PSP units then ever, just less games.