At this I honestly do not know and can not recall someone saying yay or nay before, theoretically it is just a serial port addon but in practice we have seen odd things. I do have to mention they are not emulated though -- they are running on the hardware as they would be on the original game give or take whatever save, soft reset, cheats or mod patches you might have applied.
The short version is I would not be overly surprised if it did not work with the standard patching people do to the ROMs but I would be surprised if we could not get it working at all.