I am assuming you are using the most update Beta version of usbloaderGX which is R1217 with Dios-Mios 2.10.
if you can back up all your games gc and wii and all other important data that you want to save download and install easus partition master home edition erase all partitions on your drive
then make a fat 32 partition out of the whole drive, if you don't have any pc data going on the drive that excedes 4GB in size. Wii games that are bigger then 4GB can be split using WiiBackupManager as long as "Ignore Storage Convention for transfers to WBFS file" is unchecked. and if your USB Loaders settings are correct. for the games over 4GB you'll get a 3.99 GB WBFS files and the rest of the data will be stored in a WBF1 file.
after the partition is made right-click the partition and click format use this window to format the partition to 32KB Cluster size.
Right-Click the partition again and click make primary.(Easus Partition Master will always set a partition to active so there is no need to worry about setting the partition to active as well, It was already done when you created the parition.)
Click the Apply Button in the top left corner of the main program window.This may take a few minutes depending on your computer speed and hard drive size.
Do a test run on the partition open the drive in windows explorer right-click anywhere and create a new blank text file with the stroke of the space bar, save the file, close out notepad. Right-click the text file click properties if the file is 32KB you followed all of the steps correctly so far.
Now if you don't have discex v0.9 then download it from the dios-mios webpage copy and paste the .dll files and discex.exe to the C:/Windows/System32 folder do not overwrite any existing .dll files contained in your system32 folder ever. Having discex in your system32 folder will allow you to run cmd.exe and just type discex -a,c,v "Location of iso" to run the discex software. Or you can place discex.exe and the 2 .dll files in the games folder.
download my automatic batch software that I made and haven't uploaded posted till now
http://www.mediafire.com/download/3lc8nor6ggdvg8u/AutoDiscEx_Batch.zip
Extract this zip file and place it in the games folder of your hard drive and drag n' drop your gc iso on to the appropriate batch file -c ford compress -a for auto-alignment of 32kb cluster size and no argument batch file for 1:1 copies. Having my batch files in the games folder will allow you to not take up your computers hard drive space so it's just drag and drop, wait, eject hard drive and play game.
If you have any problems after doing all of this then try a different hard drive, laptop 2.5 Inch hard drives work most of the time