No, full-drive (actually full-partition) encryption is something that's typically handled at a layer between block device (whole disk, sectors, etc) and file system
My opinion is that best should mean easiest to use on a different system.
FAT32 is king by a long way, but file size limitations (and huge block sizes for that partition size) may be objectionable
NTFS is therefore my recommendation: full support on Windows, near-full support on most other major OSes (preinstalled in most consumer Linuxes, an optional install for read/write support on most others and Mac OS)
FAT64/exFAT effectively combines the advantages of the above (after a very rough start), but it's still less popular, and the non-journaled, single-allocation-table-by-default is something I would be wary of (especially if you use write caching to improve performance)
If you are really committed to Mac OS, Linux, BDSs, etc you may choose their native file systems - but cross platform support is considerably worse