Well here are my thoughts on the lineup.
Luigi's Mansion 2 - Haven't played the Gamecube game but I'm interested in this.
Animal Crossing - I enjoy Animal Crossing and the mayor mechanic should be interesting.
Heroes of Ruin - Looks nice. The addition of online co-op and voice chat in this game is nice.
Kid Icarus Uprising - Looks like fun. Not especially excited for it but it should be fun.
Beyond the Labyrinth - Appears to be really good. I'll probably get it.
Resident Evil Revelations - Visuals look great and it appears to be a return to the survival-horror series. I'll be getting it.
Paper Mario - Might get it. I played the Wii version and that was horrible but I've heard that the original Paper Mario and The Thousand-Year Door were good.
Time Travelers - Hard to really say as there hasn't been much info on the gameplay. The time-travel mechanics and ability to affect future events seem interesting, though. I trust Level-5 to pull this off successfully. I'll get it.
Tales of the Abyss - Haven't played the PS2 version so I'll get this to see how it is.
Mario Tennis - Looks like fun and it's made by Camelot. I'll get it.
MGS 3D Snake Eater - Well the visuals aren't anything special but it appears that the frame-rate issues that this had previously were fixed. I'll get it after I beat MGS1 and 2 on the PC just so I can play MGS3 on the go.
Professor Layton and the Mask of Miracle - LAYTON, BABY. MUST-BUY.
Fantasy Life - It's made by
Brownie Brown and
Level-5! What could go wrong? Definitely getting this.
Rhythm Thief - Eh, I'm not so sure about this. Looks okay but I'm not particularly excited for this.
Bravely Default - I'll wait for more info on this game but it doesn't look too bad.
Tekken 3D Prime Edition - Not a huge fan of Tekken but I'll get it. Should be a nice fighter especially since it runs at 60FPS in 3D with online play.
Rayman Origins - I probably won't get this. If I do end up getting a portable version of Origins, it'll probably be the Vita one (when I get a Vita) because of the game's lovely visuals.
Fire Emblem - I'm not too sure about this. Might get it.
Monster Hunter Tri G - I'll get this if it does end up getting localized.
Theatrhythm: Final Fantasy - I'll probably get it after a while. Looks like a fun little rhythm game.
Kingdom Hearts Dream Drop Distance - Before I play this, I'll have to play the other Kingdom Hearts game so I know what's going on story-wise. Or I can jump right in like prowler suggested.
Crush3D - I'll get this. Looks like a fun platformer and I'm intrigued by the whole
crush mechanic.
Professor Layton vs. Ace Attorney - LAYTON + ACE ATTORNEY = AWESOME. MUST-BUY.
Rune Factory 4 - Haven't played a Harvest Moon/Rune Factory before. I probably won't get this.
Dragon Quest Heroes - While it doesn't look too bad, I probably won't get it at launch.
Mario & Sonic at the London 2012 Olympic Games - Not excited for this. Once it enters the bargain-bin, I'll probably try it out then.
Dynasty Warriors VS. - Not something I'll buy at launch but I'll get it sometime later.
Love Plus 3DS - No.
Extreme Escape Adventures: Good People Die - I wasn't amazed by 999 but it wasn't bad. I'll get this.
Shifting World - Looks nice. I'll get it depending on how it's priced.
Rollercoaster Tycoon 3DS - I'll wait and see with this.
@Guild: You missed a couple games there.