Okay so basically if I want to play MkDS with my friend it has to be multi-host(she has an r4 so I think It can work, don't know yet) however Mario Kart Ds specifically doesn't support single card hosting so I can't test it out. I also need some help cause I opened the GitHub page you sent me and I am completely lost on that page. I don't know if there's a fix or not. I was considering forwarding Mario Kart to my home screen but since it supports multi-card hosting I think it should be fine. It's in the compatibility notes from that spreadsheet
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Basically some games flat out dont work in download play from you being the host in twilight menu. In theory, multi card hosting should work, and i haven't found the fix, so if you find it please let me know