First off, you have to delete any previous configuration file you had with any previous Mupen64 build, so that you can start using the new one using a fresh RA generated configuration file to avoid unwanted results.
Next, I recommend to all those people that are using the latest Mupen64 version with the GlideN64 update, to always have Framebuffer enabled so that games suffer from the least glitches possible.
If you still encounter glitches or graphical bugs with Framebuffer ON, then try playing around with the DRAM options (color writes and depth buffer).
Also, I cannot stress this enough, but please try to save your configurations PER-GAME with this new Mupen64 + updated GlideN64 build.
Once you hit the perfect configuration scheme for a certain game, be sure to save said configuration per-game, so that other games are not affected by those changes.
I would also recommend that people start sharing configuration files for conflicting games, so that whenever someone wants to play a certain game, you can simply drag-drop the config for said game and enjoy it right out of the box without having to fiddle around with the settings too much.