I can confirm the issue that
@Stefano_Lassandro encounter on several games (the C-Nub not working if its not remapped). I encounter this on Resident Evil Revelations, Silver Falls 3 Down Stars, Terraria, Dragon Quest Xi, Dragon Quest VIII, Kingdom Hearts Dream Drop Distance, Shin Sangoku Musou VS, E.X Troopers, Snack World Trejearers, Monster Hunter Stories, Dementium Remastered, etc.
Also, if i have rehid activated, Xenoblade Chronicles, Legend of Zelda Majora's Mask and Rodea the Sky Soldier won't work, they freeze on a black screen after the 3DS logo.