I recently got (and resolved, kinda) this weird glitch where my mailbox started populating with 300 of the same letter. I've seen a few people talk about it off and on in this thread, but with no real solution, so I want to make sure my experience is documented (and so future people googling this can find it.) I only got this after save editing, using the NHSE build from 2020-04-25
So as mentioned, one day I went to play Animal Crossing, and saw that my mailbox flag was down (which is weird because I usually order a lot of shit from the Nook machine)
When I opened it up, there were 300 of the same letter, all the same. The letters were all favorite'd automatically, unopened, has presents attached, and had no text in the little preview blurb. Whenever I tried to open one of these letters, the game would just crash on me. I'm not sure if the 300 letters and the crashing are directly related, since I've seen other users that get 300 letters, but they're not actively crashing the machine (or actually contain valid presents)
I posted in another thread here to try to find what others have done to resolve (can't link yet, since I'm still a new user, but if you search 'Animal Crossing New Horizons duplicate mail' you can find it)
And a couple awesome people pointed me towards the postbox.dat and postboxHeader.dat being the issues here. I tried to download theirs to use on my save file, but that was no good, and it just made the game think my data was corrupted and needed to resolve
But I used the postbox files from my old JKSV backup, and it worked like a charm. I lost whatever was coming into the mail that day (a song or two and a Gulliver Trophy,) but that was a small price for me to pay to be able to get mail again
Here's what was edited on my file:
Villager 5 (Bob) had his catchphrase replaced from his original 'pthhhbth' or whatever it is to 'ay lmao' because I thought that would be hilarious
Villager 6 was Yuka and was replaced with Audie. We entered all of her data wholesale, including personality, catchphrase, etc. (Her house is still a bit odd, since it's still Yuka's but not too concerned about it) So Species, Variant, Personality, and Catchphrase were all changed here
Villager 8 was marked as 'moving out' so that we could replace her with someone more interesting via amiibo. Hit both the checkbox and set the moving out flag to 1
Player 1 was given a pile of money and tickets and a stack of each fruit
Player 2 was given a pile of money and tickets and a set of golden tools
My guess is that one of the Villager edits didn't play nice with the version of the NHSE I was using (build was from 2020-04-25,) and didn't set all of the data properly for one of them (I'd guess V6, but I can't say.) So that when that villager sent me a letter out of the blue, it tried to access something, like a catchphrase, in the game data, was unable to parse whatever it found, and then blew up, and sent me 300 letters.