simple you can't change the directory put isos in wisx/isos/
are you using the updated version with enchanced usb support?
http://gbatemp.net/threads/wii64-and-wiisx-recompiled-improved-usb-support.295936/
format your usb drive in fat32 32k MBR primary to fix. not GPT and not logical. use the Easeus partition master and immediately format again with wii backup manageri need some help playing games from usb? on the usb i have made it like this wisx/isos/game. but is just says error opening directory : usb/wiisx/isos. what is the problem?