I have a 1T drive split 50/50 fat32 and wbfs
I use my fat32 for video and a backup of the stuff on my SD card. (I'd love to not use the SD card at all, but booting my stuff off the fat32 partition is slower and only works like thalf the time.
The wbfs is just for games. (I guess thats obvious)
I don't want to deal with fat32 and .wbfs files just because I don't want to mess with split files and the 4G file size limit.
When you can rip games straight to NTFS, I'll probably switch everything over to a single NTFS partition. Thats honestly my biggest problem with it at the moment. if I went to NTFS now I'd still need some partition as fat32 or wbfs to rip the games onto, then transfer them over to the ntfs.