Only if the problem IS the filename.
If your ISO's data is corrupted, renaming the file will never fix the data.
"USB Loader" is not enough information, as different USB loader require different configurations.
But generally, you need to place the iso here:
Drive_letter:\wbfs\ name of your game [GAME ID in 6 LETTERS]\GameID6.wbfs (or .iso)
Example:
F:\wbfs\Zelda Skyward Sword [SOUP01]\SOUP01.wbfs
But, do not do it manually, there are programs which are doing it automatically to prevent any error caused by a user's wrong doing.
The program will rename it correctly, with the correct Game ID, in the correct folder, etc.
Download
WiiBackupManager to transfer your ISO to your HDD.
In the program option, select the folder format as
Game_title[GameID]