Seems like install speed is the only difference, but there's probably some behind-the-scenes stuff I don't know about.
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No issues whatsoever - just finished playing through Metroid Fusion, Castlevania HOD and Pokemon LiquidCrystal (a mod). I just switched to the march 4th builds yesterday, however, and still haven’t had issues, but I haven't used it that much. Here is a link to the Feb 26 builds (CIA only, sorry), in case you want to test it.
https://mega.nz/#!TYR1kTrJ!0ud-imayN5AAJy5rwHzZ74jxQY6Kx0PrqCp09M_7BnQ
EDIT - Whoops, double post.
EDIT2 - N3DS, 10.6 Rei, 9.2 sysNAND. Also using NTR CFW 3.3