Well the G6DSR 16Gb is only 2GB end of story and if you need more space you cant!
And if you get so unlucky to break to memory then its a dead unit..
How ever the R4 has unlimited GB (as much as your microSD's have) and if they get broken you still have the R4!
I recommend the R4
I honestly don't see why you'd need more than 2GB. I have the 8Gb model, and 1 gig seems to fill up all the games that I want to play. And even then, I really don't need them all. I went with the G6 because of the Wii support, and also I'm tired of fussing around with external media. Especially things the size of your finger nail.
Like it was said near the beginning, couldn't be easier. Ya just plug it into the usb device, drag & drop, and you're good. I haven't had a problem yet. And the only problem with the 16Gb was homebrew not functioning right, but that's just been fixed with v2.3.
I will admit though, I was first considering an R4. But I have absolutely no regrets about getting a G6. Either way, I'm sure you'd be happy. I'd break it down like this:
The R4 has the advantage of having multiple cards for more space and is cheap. But even if it's cheap..ya gotta buy the card, unless ya have one lying around already. Also no Wii (PBR) support at the moment, but I'm sure that could be fixed in the future. When though I don't know.
The G6 is all in one so no bothering with little cards. But, you can't get more space if for some reason you need it. It's got Wii support. And the Download Play isn't perfect as they advertised it, but it's really good, and will for sure be fixed in due time.
Might have missed a few things, but based on that, if you still don't know which one to get, then don't stress it. Just choose one, they're both good. You'll be happy with your purchase. That fact that people are talking about these 2 cards so much comparing them shows that they're both worth something.