I'm sure it can be done. The DS has been shown to be able to be capable of FMV, So Sega CD and PC-Engine CD games won't be much of a problem save for the multi-disc games. 32X might take some time. PS1 is barely working on even the DSi, and plus both the PSP and PS Vita have better handling of it. But what about earlier 5th gen stuff like the FM Towns Marty, Amiga CD32, and the 3DO Interactive Multiplayer?