I assume you mean Duke 3d.
In that case yes, it is much like Doom in that it get ported to just about everything https://www.gamebrew.org/wiki/Duke3DS
Many mods will not work well with it but the baseline game should just about be playable through to the end.
There is also a version for the GBA, but like most ports of games like it on the GBA it is not very good, especially not with what we otherwise have to play with today.
Edit. Also do avoid the commercial duke nukem game on the DS... unless you really want to see bad games.
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