Oooh, THAT game!
Welp, I think night->day transition would take a few seconds more than on PC, and the visible screen portion would be reduced, but otherwise it would be portable
I think there would be hiccups on old3DS in some places, but since I have an old3DS, I would optimize the soul out of it
Since this is not a fast-action game, I wouldn't need some crazy collision detection, so it should be doable
Edit: or just make an asset hack on one of the Harvest Moon games