1. You don't need to bump topics. Someone will get to them eventually.
2. Region is irrelevant for most (not all) games when playing through loaders. In general, you're probably best off playing games in your own region, but an alternative region is typically fine if your region isn't available. If you get an oddly-colored picture or choppy lines on the screen, try forcing your video region in the loader options. Other than that, no differences.