If it's a text-only e-book, you'd be better off converting it to .txt and reading it with a dedicated text reader (like Moonshell, DSReader, etc). If it has lots of pictures, consider converting it to a series of JPEG images and reading with ComicBook DS.
ANDS-PDF is good as a proof of concept, and does load many PDF files, but for actual book reading I'm not sure if it will be sufficient.