Depends, you can do the metroid prime 3 trick, I think. Where you boot a copy with the update, let the update go for 10-15% and turn off the wii, and then boot the brickblocked copy.
I heard that it worked on Mario Galaxy as well as Metroid Prime 3. However, Nintendo tries to out-do hacks like brickblocker, which is why it doesn't work with MP3 and SMG in the same way it works with most other games.
And I'm willing to bet that Nintendo is going to try some new copy-protection on this game as it is the must-have for the console. It's the game that's going to define the system.
So: Worst case scenario, brickblocker and the metroid prime 3 trick don't work, and the game has an update. You update your NTSC-U system with parts of the Japanese firmware and your system is completely bricked. You power it on and it gives you an error that only Nintendo will be able to fix.
Medium/Bad: Brickblocker and the metroid prime 3 trick don't work, and the game has an update. You update your NTSC-U system with parts of the Japanese firmware and your system is half-bricked, so whenever you try to access your wii's settings, it pops up with an error. This also erases all your network settings, so you can no longer connect to the internet with the Wii. However, it's still able to play games from DVD and VC stored on the systems' flash memory.
Good: The game either works with brickblocker (unlikely) or doesn't have an update that will be applied to the most recent of NTSC-U firmwares (likely), and you play the game without updating at all, or update and no noticably bad things happen to your wii (most likely).
Most Probable: The game will have some new copy-protection that will take chip makers some time to workaround, so you don't even have to worry about updates, because your Wii won't run the game with the current firmware on your modchip.
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