I have not experienced this error myself, but this sort of problem is commonly caused by the card reader.
At least one person has said that they had no problems with the reader that came with th R4, but they did have problems with a different one. It's usually the other way around.
Try it in the reader that came with the R4. It's highly unlikely that it will destroy your card, or burn your house down. I have that same clear blue card reader and it seems to work. I had one minor problem once (a zero byte file that wouldn't delete) that I assumed was caused by the reader, but other than that it worked fine.