I have tried the following games:
Animal Crossing - New Leaf (USA) (RF)
Harvest Moon 3D - A New Beginning (USA) (RF)
Myst (USA) (RF)
Nintendogs + Cats - Golden Retriever and Friends (USA) (RF)
Those are not legit CIAs, and thus they won't work unless you use CFW or patch signature checks. Legit CIAs are ones that are dumped from a console that is bundled with a game. If you look on
That ISO Site you will find several postings for legit CIAs, most of which contain every single legit CIA that currently exists (which isn't a whole lot, and varies by region)
As far as I know only pokemon games come region free as a legit CIA, the rest are region locked, meaning if it says region-free and it isn't pokemon it is guaranteed to not be legit.
Edit: Clarification, only that game bundled with the console can be dumped as a legit CIA. So basically if it came bundled with a console there exists a legit CIA for it if it was dumped by someone.