What to do with the information we have today:
Average Desktop User (Intel): At this point your best and only option is to apply the Microsoft KAISER patch when they become available. As this attack is also reported to have delivery via web-browser via .js, it may be plausible to block .js execution from the browser as well.
Average Desktop User (AMD): Hold tight. AMD is adamant that these exploits do not affect their architecture. If anything changes, we are actively tracking and will alert you.
The Gamer (Intel): Performance impact benchmarks have not been done yet, so we really have no idea how much of a performance hit your favorite video games will take. You could risk it and keep Windows from updating, but we would not recommend that currently.
The Admin: This is going to boil down to company policy. You will have to weigh the unknown vs. the known. Are the patches compatible with your AV suites? Will they cause an adverse business impact when deployed? Will performance impacts cause issues and what could they affect specifically? If it was us, we would look at critical systems and start there. Sensitive data being protected is a priority.