This fight will never end.
SX Pro (the full kit) is the easiest way to mod your Switch. Period. Is it the best option? Depends. To me SX is the best simply because of .xci files and how you can mount them instead of installing them (functions exactly like inserting a game cartridge, so you can only mount one game at a time, but it's pretty fast and smooth). I don't know if .xci is safer or not, but for sure it is the easiest, fastest and most natural way to load your games and play.
Plus: the cheat engine in SX OS is solid and very “integrated” to the OS.
Buy SX Pro and be happy.
The easiest way to mod your switch? Hardly true anymore. Kosmos is incredibly easy as well(Really just drag and drop files, how hard is that?) as is the AtmosPP pack by Switch Pirates. there is no safety difference between .XCI and .NSP and while it might be the fastest way, it's most certainly not the easiest nor most natural(The hell does that even mean anyway?) As for the cheat engine you are aware that Atmosphere has that too right? And that it's also integrated into itself?