A)You can now choose the gender of the Main Character.
B)Daytime exploration is now point and click and the characters on the map have become 2D sprites. You can also now see your main character's portrait while exploring the map (daytime only)
C)While in Tartarus exploration is the same. There's also now an autosave feature in Tartarus.
D)S.Link scenes and conversations have a visual novel style.
E)There are now 5 difficulty settings.
F)There are new costumes.
G)You can now directly control your teammates in battle along with some other Persona 4 battle elements like your teammates taking a mortal blow for you.
H)Skill cards are now in the game. (How they are used isn't actually known other than they could be used to give other personas skills)
I)Fusion Skills can be used with items. (It isn't confirmed if this is the only way that they can be used)
J)New portraits for characters.
K)S.Link scenes will be voiced Persona 4 style.
L)''Tired'' status can be cured using items.
M)Entering your dorm room won't change the time.
N)There are Persona 4 cameos (so far Kashiwagi and Yukiko are confirmed to appear as cameos).
O)There is now a new ''Vision Quest'' that some theorize is a boss rush mode, this isn't confirmed.
P)There is no ''The Answer''.
Q)Anime cutscenes have been removed and replaced with in-game graphics cutscenes.
R)Other unknown additions have been added to the Male Protagonist's route.
S)P3FES' additions and changes are still present along with these new ones.