You'll just have to muck around with your USB control until you find what the cause is. I'll be different with every PC/OS/SP.
Many others have their drives working in enclosures so I would say there will not be much more development in this area, especially considering the device is working in debug mode.
I won't say I'll be able to help you fix it, as every PC I've configured over the years (100's) have their own crazy "ism's".
Just to start you off, check your BIOS, for instance, legacy settings, etc. etc. Again, different for every mobo. Good luck.