FreeMultiPatcher allows you to use Out of region cardriges and CIAs, but it has some problems with out of region dlc, and games that need the language emulation plugin from ntr, to work on an other region. Also it allows you to use the eshop on all devices thta have 9.0.0-20 or higher, without the need of a pc to apply the patch manual.
With the next release it will also allow you to create an use own patch files, but it doesn't allow you to cheat like ntr at the moment.
Both application could be use at the same time, but ntr will fail to but(and you have to wait a moment to (5-10sec) to have a higher boot rate.
If you are fast enough to start the cfw and the free multi patcher, to apply the patches after the boot, you also wont need unwrap all installed games every time. After that start NTR, and you have nearly full regionfree.
Also starting a application using the touchscreen is faster than using the buttons.