The first things to try would be deleting or renaming usb:/sneek/diconfig.bin and usb:/nands/xxxx/sneekcache/channelcache.bin.
A few more questions:
What version of neek2o are you using? Did you build it with modmii?
What system menu are you using? Are you using a backup of your own nand or a modmii created one?
Do you have priiloader installed on that nand? Can you access it's setup screen by holding the reset button when the system boots into neek2o?
How do you boot into neek2o?
Is your dvdtray light flashing, or does it stay off?
A few more questions:
What version of neek2o are you using? Did you build it with modmii?
What system menu are you using? Are you using a backup of your own nand or a modmii created one?
Do you have priiloader installed on that nand? Can you access it's setup screen by holding the reset button when the system boots into neek2o?
How do you boot into neek2o?
Is your dvdtray light flashing, or does it stay off?