This issue is getting a bit tedious. I've seen it mentioned in many different threads, and IIRC even referenced as a caveat on one of the backup-loader compatability lists that have been set up. It's NOTHING TO DO WITH THE LOADER.
If people searched a bit more they'd learn that the issue in Chapter 2-2 affects RETAIL COPIES OF THE GAME too. It was a bug in the original game - nothing to do with the loader(s).
The bug ONLY appears if you satisfy the following condition when playing:
If after speaking to Mimi for the first time (when she tells you to go and find a key) you go back to her and speak again WITHOUT first getting the key, it'll hang the moment you talk to her for the second time.
If you find the key BEFORE speaking to her again, then there's no crash. So, just speak to her the first time, work out what to do to get the key (or use a FAQ) then go back to her and it'll all be fine.