Outside of really old school things with slot in chips to make something into a quasi PC, and maybe some people having some fun with the C64 SID sound chips in PC cards (said chips also seeing modern pin compatible recreations) has there been anything like this for any system in recent years? I would not expect to see much of this outside of serious cheat setups, video capture and play for disabled people where inputs/macros are generated PC side and fed to the console's pins, maybe with some memory reads to aid matters.
Most people tend to come the other way and try to replicate aspects of a device in a FPGA and stick that on a PCIe card or something so they can offload something into a transistor accurate... recreation I guess it would be (though that might be more of an ideal as FPGAs are not magic). I have not seen that for the N64 either (most people tending to go for more well known chips or well known consoles, usually in older or simpler devices as FPGAs mortals can afford tend not to have that many gates -- a quick scan around says the N64 CPU was in the millions of transistors but the SNES one low tens of thousands).