Pretty sure there's ScummVM for the DS and that's like point and click heaven.
Everyone says "OMG ACE ATTORNEY" but I found it just awful. The characters are stupid (just HURR HURR HURR I'M FUNNY ACTING) and the story was very mediocre. Only good part was the court battles but even those were terribly trial (no pun intended) and error.
There's Broken Sword: Shadow of the Templars which a lot of people liked.
On other consoles though there's Monkey Island, Beneath a Steel Sky, and Sam and Max.
EDIT: On the DS there's also Hotel Dusk (which people apparently liked), Again (got crappy reviews though), and a few others. I'm not really a fan of the genre though, I just somehow know a few point and click games.