Most game don't work or will having trouble. Burning it on the disk then use Neogamma to load it is your best option. Be aware that some GC games will have audio issues. WODE is the only option that lets you play GC games 100% correctly.
Even the WODE has issues with GC games that have streaming audio. Starfox Adventure for one. But the WODE has the best compatibility anywhere. Just out of curiosity, why wouldn't that be an option? The price? The opening of your Wii? Honestly, both things are outweighed by the sheer awesome that is the WODE. The value is justified by just how many games become available to you.
Actually wode doesn't have the highest compatibility - a proper drivechip has the highest compatibility with GCN games. Wode is the best solution if you want to load games from USB, but if you want all games t play and sound as they should then a drivechip is required.