I've read some other topics on this, but I still can't make up my mind. Currently I only have 4 Wii games backed up. They are in .wbfs format (I have the .iso's for some of them) and they are on a WBFS formatted drive. I have a 1TB hard drive that I want to use for backing up Wii games. I use about 300GB of the HDD to back up files from my computer. None or very few of the files from my computer are >4GB so in that respect FAT32 shouldn't be a problem and if I do end up having some files >4GB then I should be able to split them with Winrar or something similar. I want to put as much as I can on my HDD, but I have an SD card and it's no problem for me to run HB or USB loader or anything else from my SD card, so I don' mind too much if I can't load them from my HDD but it would be a plus. I also really like the ability to rip Wii games to my HDD using USB loader and I've heard tha NTFS doesn't support this. Overall it's looking like I'm going to be using FAT32, but I know there are disadvantages. People say that you should use NTFS if you store computer stuff on your HDD, which I do, but like I said, very few if any files are >4GB, so if that's the only advantage NTFS has over FAT32 in terms of computer storage, then I don't care, but I feel like there are downsides that I'm missing.